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4. Investigation of the co-carcinogenicity of exposure to magnetic fields

Even if low-frequency magnetic fields are not carcinogenic according to current scientific knowledge, there is in principle the possibility that they could have a co-carcinogenic effect. In this regard, it should be examined whether magnetic fields can enhance the effect of carcinogenic environmental agents and substances (including ionizing radiation and certain chemicals). The conduct of animal studies and in vitro studies on the co-carcinogenicity of low-frequency magnetic fields was given high priority by the WHO in 2007 (WHO, 2007). Two studies by Soffritti et al. in Sprague-Dawley rats showed significantly increased incidence rates for several tumor types when the animals were exposed to 50 Hz magnetic fields and an additional dose of gamma radiation or formaldehyde in the drinking water (Soffritti et al. 2016, Soffritti et al. 2016). The studies are from the same working group and have not yet been independently replicated. Experimental in vitro studies mostly do not indicate a co-carcinogenic effect of magnetic fields (Gholipour Hamedani et al. 2022, Jin et al. 2015, Jin et al. 2014, Yoon et al. 2014, Lee et al. 2012).

Research project

4. Investigations of the co-carcinogenicity of exposure to magnetic fieldsShow / Hide

Since the mentioned publications above, there is no growing evidence for a possible co-carcinogenic effect of low-frequency magnetic fields. For this reason, the research project, which was already planned with a low priority, will not be carried out as part of the current research program. The decision was presented in the technical discussion held in May 2022 on the status of the BfS research projects in the areas of power grids and mobile communications and was supported by the experts present. The BfS continues to follow and evaluate the study situation on this topic and will - should the need arise - initiate research on this.

Literature

WHO - World Health Organization. Extremely low frequency fields. Environmental Health Criteria, Vol. 238. Geneva, World Health Organization, 2007.

Soffritti M, Tibaldi E, Padovani M, Hoel DG, Giuliani L, Bua L, et al. 2016. Life-span exposure to sinusoidal-50 hz magnetic field and acute low-dose γ radiation induce carcinogenic effects in sprague-dawley rats. International journal of Radiation Biology 92(4):202-14. doi: 10.3109/09553002.2016.1144942.

Soffritti, Morando, et al. "Synergism between sinusoidal‐50 Hz magnetic field and formaldehyde in triggering carcinogenic effects in male Sprague–Dawley rats." American journal of industrial medicine 59.7 (2016): 509-521.

Gholipour Hamedani B, Goliaei B, Shariatpanahi SP, Nezamtaheri M. An overview of the biological effects of extremely low frequency electromagnetic fields combined with ionizing radiation. Progress in Biophysics and Molecular Biology. 2022;172:50-59. doi:10.1016/j.pbiomolbio.2022.04.008

Jin H, Yoon HE, Lee JS, Kim JK, Myung SH, Lee YS. Effects on g2/m phase cell cycle distribution and aneuploidy formation of exposure to a 60 Hz electromagnetic field in combination with ionizing radiation or hydrogen peroxide in l132 nontumorigenic human lung epithelial cells. Korean J Physiol Pharmacol. 2015 Mar;19(2):119-24. doi: 10.4196/kjpp.2015.19.2.119. Epub 2015 Feb 25. PMID: 25729273; PMCID: PMC4342731.

Jin YB, Choi SH, Lee JS, Kim JK, Lee JW, Hong SC, Myung SH, Lee YS. Absence of DNA damage after 60-Hz electromagnetic field exposure combined with ionizing radiation, hydrogen peroxide, or c-Myc overexpression. Radiation and Environmental Biophysics. 2014 Mar;53(1):93-101. doi: 10.1007/s00411-013-0506-5. Epub 2013 Dec 5. PMID: 24305851.viron Biophys. 2014 Mar;53(1):93-101. doi: 10.1007/s00411-013-0506-5. Epub 2013 Dec 5. PMID: 24305851.

Yoon, Hye Eun, et al. "Increased γ-H2AX by exposure to a 60-Hz magnetic fields combined with ionizing radiation, but not hydrogen peroxide, in non-tumorigenic human cell lines." International Journal of Radiation Biology 90.4 (2014): 291-298.

Lee HJ, Jin YB, Lee JS, Choi JI, Lee JW, Myung SH, Lee YS. Combined effects of 60 Hz electromagnetic field exposure with various stress factors on cellular transformation in NIH3T3 cells. Bioelectromagnetics. 2012 Apr;33(3):207-14. doi: 10.1002/bem.20700. Epub 2011 Sep 6. Erratum in: Bioelectromagnetics. 2014 Jan;35(1):76-7. PMID: 21898471

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