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Home > Research > European Radiobiological Archives (ERA)

European Radiobiological Archives (ERA)
ERA





Federal Office for Radiation Protection, University of Cambridge
A large number of long-term studies on experimental animals exposed to ionising radiation have been performed world-wide in the past. Large-scale experiments involving tens of thousands of animals are unlikely ever to be conducted again for financial and ethical reasons. The possibility of returning to mine the existing data in new ways adds enormous added value to the original funding of these studies. The retrospective analysis of earlier animal studies is an important resource for modelling and evaluating new risk parameters. With great foresight the European Union (EU) and European Late Effects Project (EULEP) have created a database collecting and collating data from almost all of the available animal radiation biology studies carried out in Europe. This database is called the European Radiobiology Archives (ERA). Comparable archiving activities were initiated in the USA (establishing the National Radiobiology Archives (NRA)) and in Japan (establishing the Japanese Radiobiology Archives (JRA)). The three archives include data from almost all radiobiological animal experiments carried out between 1960 and 1998 in Europe, USA and Japan. This information is jointly available in the ERA database. ERA alone includes 151 studies from 21 labs.

The German Federal Office for Radiation Protection (BfS) and the University of Cambridge (United Kingdom) have jointly conducted a project funded by the European Community, named ERA-PRO. The project was aimed to update and promote the European Radiobiological Archives and to transfer the existing database into a version which will be accessible on the internet. A user-friendly interface was installed which allows the interested scientist to search and retrieve relevant information either on study description, on groups included in single studies, or even on individual animals. This information allows further analyses of data from radiobiological experiments with animals, mostly mice.

The following table gives an overview on the information that is available in the archives (the access to data from human studies is not yet realized):

  Labs Studies Groups Individuals (animals and humans) total Individuals (animals and humans) with data Humans total Humans with data
ERA 21 151 4,623 241,077 97,719 8,490 4,274
NRA 11 143 1,861 190,471 115,801 0 0
JRA 14 40 367 31,976 5,835 2,439 2,439
Sum 46 334 6,851 463,524 219,355 10,929 6,713


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