Investigations on genetic factors of individual radiosensitivity in lung cancer families - 3605S04454
BFS-RESFOR 24/09 urn:nbn:de:0221-2009100619
Summary
Aim of the research project was the investigation on heritability of radiation sensitivity in families and the association between various genetic polymorphisms in DNA (deoxyribonucleic acid)-repair genes with extended radiation sensitivity. Additionally, lymphoblastoid cell lines of the investigated families were generated from isolated lymphozytes of the families investigated to create a biobank. In the case-control- as well as in the family study we found several genes of the BER- (Base Excision Repair) and the NHEJ-repair pathway (Non Homologous End Joining) significantly associated with lung cancer and DNA repair capacity after in vitro irradiation, respectively. A heritability of more than 70% was found for the basic DNA damage, an indicator for radiation sensitivity and for the DNA damage immediately after the experimental irradiation.
